Differences between batch and fed batch

BATCH :

1. It is a closed system.
2. Nothing is added or removed during fermentation.
3. Not used to overcome catabolite repression.
4. Large size vessels are required due to slow growth rate.
5. Cannot extended the growth rate and the phases.
6. Volume remains constant.
7. Less chances of contamination.
8. Less efficient.
9. Primary and secondary metabolite are produced

FED-BATCH:

1. Semi-closed system.
2. Substances are added in a small dose during productive phase (periodically).
3. Used to overcome catabolite repression.
4. Can be run in a simple bioreactor. No need of specialized instruments.
5. Production phase of process may be extended using cyclic fed-batch cultures.
6. Volume increases.
7. Intermediate chances of contamination.
8. Product yield is more.
9. Secondary metabolites are generally produced (e.g., Penicillin)