Granulosa cells or follicular cell is a somatic cell of the sex cord that is closely associated with the developing female gamete (oocyte or egg) in ovary of mammals.
The major function of granulosa cell include the production of sex steroids as well as myriad growth factors thought to interact with the oocyte during the development. The sex steroids production begins with FSH from the anterior pituitary, stimulating granulosa cells to convert androgens (from thecal cells) to estradiol by aromatase during follicular phase of menstrual cycle.
LH (Luteinizing hormone) is a hormone produced by gonadotropic cells in anterior pituitary gland. In females an acute rise of LH surge trigger ovulation and development of corpus leuteum.
The increase in LH production only last for about 24 to 48 hours. This LH surge trigger ovulation thereby not releasing the egg from the follicle but also initiating the conversion of the residual follicle into a corpus luteum that in turn produce progesterone to prepare the endometrium for a possible implantation. LH is necessary to maintain luteal function for the second two weeks for menstrual cycle. If pregnancy occurs, LH levels will decrease and luteal function will instead be maintained by the action of hCG (Human chorionic gonadotropin) a hormone similar to LH but secreted by new placenta.
The major function of granulosa cell include the production of sex steroids as well as myriad growth factors thought to interact with the oocyte during the development. The sex steroids production begins with FSH from the anterior pituitary, stimulating granulosa cells to convert androgens (from thecal cells) to estradiol by aromatase during follicular phase of menstrual cycle.
LH (Luteinizing hormone) is a hormone produced by gonadotropic cells in anterior pituitary gland. In females an acute rise of LH surge trigger ovulation and development of corpus leuteum.
The increase in LH production only last for about 24 to 48 hours. This LH surge trigger ovulation thereby not releasing the egg from the follicle but also initiating the conversion of the residual follicle into a corpus luteum that in turn produce progesterone to prepare the endometrium for a possible implantation. LH is necessary to maintain luteal function for the second two weeks for menstrual cycle. If pregnancy occurs, LH levels will decrease and luteal function will instead be maintained by the action of hCG (Human chorionic gonadotropin) a hormone similar to LH but secreted by new placenta.
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