Thyroxine is the main hormone produced by the thyroid gland and control the body's basal metabolic rate (BMR). A person's basal metabolic rate refer to the minimum number of calories needs to survive in the absence of any activity. Every cell in the body depends on thyroid hormone for proper metabolism. The iodine containing hormone control neural development as well as releasing fat from most of the fat cell controlling metabolism and affecting growth. A lack of thyroxine contribute to growth disorder. Too much thyroxine causes a BMR that is too high. Too much thyroid hormone in blood stream can create extreme in body weight due to difference in basal metabolic rate. Thyroid hormone stimulate diverse metabolic activities leading to an increase in basal metabolic rate. Increased thyroid hormone level stimulate fat metabolism and mobilization, leading to increase of fatty acid in plasma. Also enhances oxidation of fatty acids in many tissues. Also thyroid hormones stimulate almost all aspect of carbohydrate metabolism, including enhancement of insulin-dependent entry of glucose into cells. Thyroid hormones regulate the rate of cellular metabolism. Hyperthyroidism-in which there is increase in production of thyroid hormone- leads to high BMR, while hypothyroidism- in which thyroid hormone are depleted-cause a low BMR.
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