CSF (cerebrospinal fluid) is a clear, colorless body fluid in the brain and spinal cord. It is produced in the choroid plexuses of the ventricles of the brain, and absorbed in the arachnoid granulations. CSF acts as a cushion or buffer for the brain providing basic mechanical and immunological protection to the brain inside the skull. It also severs a vital function in cerebral autoregulation of cerebral blood flow.
CSF is derived from blood plasma and is largely similar to it, except that CSF is nearly protein-free compound compared with plasma and has some different electrolytes levels. Due to the way it is produced, CSF has a higher chloride level than plasma and an equivalent sodium level.
CSF contains approximately 0.3% plasma proteins. In general, globular proteins and albumin are in lower concentration in ventricular CSF compared to lumbar or cisternal fluid. This continues flows into the venous system dilutes the concentration of larger, lipid-insoluble molecules penetrating the brain and CSF. CSF is normally free of red blood cells and at most contains a few white blood cells.
CSF is derived from blood plasma and is largely similar to it, except that CSF is nearly protein-free compound compared with plasma and has some different electrolytes levels. Due to the way it is produced, CSF has a higher chloride level than plasma and an equivalent sodium level.
CSF contains approximately 0.3% plasma proteins. In general, globular proteins and albumin are in lower concentration in ventricular CSF compared to lumbar or cisternal fluid. This continues flows into the venous system dilutes the concentration of larger, lipid-insoluble molecules penetrating the brain and CSF. CSF is normally free of red blood cells and at most contains a few white blood cells.
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